03 Pyrimidine
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Synthesis
- create monophosphate version
- II: found in cytosol, rate limiting, inhibited by UMP
- I: in mito, for urea cycle
- bifunction: catalyzes 2 steps
- hypersegmented neutrophils
- letter U: orotic acid in Urine, Ump synthase, Uridine treatment
Thymidine
- adding methyl group to create thymidine
- folate to THF, add carbon to dUMP
- humans don't rely on PABA to make folate
- deficient in B12: all folate trapped in N5 methyl THF
- deficient in either folate or B12 leads to high homocysteine level
- MMA: fatty acid conversion
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